Drug Repurposing (Drug Discovery Series, Volume 82) (Original PDF from Publisher)

Drug Repurposing Drug Discovery Series

Drug repurposing, or the development of existing medications for new uses, is an appealing and intrinsically more efficient method because nine out of ten drugs that go through drug development are never marketed, representing lost effort. For the same price as a single novel chemical entity, three repurposed medications can be introduced to the market. They can also be identified more rapidly, which is beneficial for patients whose illnesses are developing more quickly than new therapeutic approaches. However, repurposing also necessitates a new approach to pharmaceutical R&D configuration, taking clinical, regulatory, and patent difficulties into account much earlier than would be the case otherwise; a comprehensive gedanken experiment practically has to be conducted from the outset of any repurposing research. Along with fresh perspectives, the identification of repurposing prospects can leverage artificial intelligence approaches to find the ideal new application for an existing medication. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.